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Southeast Asian J Trop Med Public Health ; 1998 Dec; 29(4): 758-62
Article in English | IMSEAR | ID: sea-33137

ABSTRACT

Studies involving infectious, wild type HIV-1 must be performed under strict BSL-3 practice. We have employed a defective (deltaTat/Rev)MC99 and cloned 1A2 line, ie, mutated HIV-1 and Tat/Rev transfected cells to verify anti-HIV-1 activity in a BSL-2 laboratory. A number of extracts from various parts of 11 species of plants were studied. Results were correlated with those of an anti-HIV-1 reverse transcriptase (RT) assay.


Subject(s)
Anti-HIV Agents , Biological Assay/methods , Cytoprotection/drug effects , Drug Design , Giant Cells/drug effects , HIV Reverse Transcriptase/antagonists & inhibitors , Humans , Laboratory Infection/prevention & control , Plant Extracts/therapeutic use , Reverse Transcriptase Inhibitors
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